Arsenic is a harmful element that can cause cancer. In arsenic-contaminated soils, this element can be absorbed and accumulate in rice. Because rice is the main food source for more than half of the global population, arsenic in rice is a matter of special concern to the scientific community. Most rice growing plains in the world accumulate Arsenic. Therefore, Arsenic accumulation in rice is considered one of the major risks (besides climate change) that can impact wet rice cultivation, food security and food safety on a global scale. Because Arsenic is available in soil and sediment, the absorption and accumulation of Arsenic in rice is considered “irreversible”. However, the limit of Arsenic absorption and accumulation depends on the physical and chemical factors of the soil environment. Therefore, developing appropriate farming techniques can also partly limit the absorption and accumulation of Arsenic. In the context of many major environmental changes such as climate change, saltwater intrusion, increased pollution; and with rapid changes in breeding, fertilizer, and irrigation techniques, the level of Arsenic accumulation in rice is likely to change. This project was carried out to predict the future trend of Arsenic accumulation and propose appropriate technical solutions to improve rice quality, contributing to limiting negative impacts on public health and ensuring livelihood for millions of workers in rural areas.